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       近日，清原農(nóng)冠環(huán)吡氟草酮（cypyrafluone）等專利化合物獲巴基斯坦農(nóng)業(yè)部的批準登記，這是該系列產(chǎn)品在海外的首次登記，標志著清原農(nóng)冠正式啟動國外銷售，進軍海外市場。

       環(huán)吡氟草酮（cypyrafluone）是清原農(nóng)冠自主創(chuàng)制的對羥苯基丙酮酸雙氧化酶（HPPD）抑制劑類除草劑專利化合物，已于2018年8月30日獲得中華人民共和國農(nóng)業(yè)農(nóng)村部正式登記。這是HPPD抑制劑首次用于小麥田防除禾本科雜草，與當前小麥田其它除草劑都不存在交互抗性。

環(huán)吡氟草酮結(jié)構(gòu)式

環(huán)吡氟草酮獲巴基斯坦批準登記

       清原農(nóng)冠進軍海外，巴基斯坦在亞洲市場上具有重要的戰(zhàn)略意義。據(jù)了解，巴基斯坦是典型的農(nóng)業(yè)國家，以種植業(yè)為主，糧食作物主要有小麥、水稻、玉米等，其中小麥種植面積約占全國耕地總面積的40%。但是農(nóng)民備受小籽虉草（Phalaris minor）等雜草困擾，由于小籽虉草（Phalaris minor）對當?shù)刂髁鞒輨┊a(chǎn)生抗性，且長勢強，繁殖系數(shù)高，傳播速度快，嚴重影響巴基斯坦的農(nóng)業(yè)生產(chǎn)。

清原農(nóng)冠工作人員與當?shù)剞r(nóng)戶交流田間雜草情況

       為提升世界農(nóng)業(yè)生產(chǎn)的效率和品質(zhì)，保障世界糧食安全，清原農(nóng)冠在巴基斯坦開展了科學防除雜草的實驗。實驗證明，環(huán)吡氟草酮（cypyrafluone）能高效防除當?shù)匦∽烟埐荩?em>Phalaris minor）等大部分小麥田雜草，幫助農(nóng)民極大地節(jié)約種植成本。

清原農(nóng)冠工作人員深入當?shù)靥镩g調(diào)研

       除環(huán)吡氟草酮（cypyrafluone）以外，雙唑草酮（bipyrazone）也同步獲得了巴基斯坦的批準登記。未來，三唑磺草酮（tripyrasulfone）、苯唑氟草酮（fenpyrazone）也將在巴基斯坦登記上市。雙唑草酮（bipyrazone）、三唑磺草酮（tripyrasulfone）、苯唑氟草酮（fenpyrazone）均是清原農(nóng)冠自主創(chuàng)制的全新HPPD抑制劑。雙唑草酮（bipyrazone）可安全用于小麥田高效防除抗性及多抗性播娘蒿、薺菜、繁縷等闊葉雜草；三唑磺草酮（tripyrasulfone）是多抗性稗草、千金子的頂級解決方案，它首次將HPPD抑制劑安全用于水稻田苗后莖葉噴霧處理；苯唑氟草酮（fenpyrazone）對煙嘧磺隆抗性雜草馬唐、稗草、紅根谷莠子等不存在交互抗性，是玉米田優(yōu)秀的ALS抑制劑抗性雜草管理方案。

雙唑草酮、苯唑氟草酮、三唑磺草酮結(jié)構(gòu)式

       此外，清原農(nóng)冠已經(jīng)在巴基斯坦、印尼、柬埔寨等6個東南亞國家開展農(nóng)藥登記，共22個登記項目，已經(jīng)取得登記13個，還有9個正在進行中。

       據(jù)悉，截止到2021年11月底，清原集團已申請中國發(fā)明專利189件，已授權(quán)84件；已申請PCT國際發(fā)明專利113項，通過PCT途徑或巴黎公約途徑進入世界各國家累計達763件，累計已有157件獲得授權(quán)。目前，清原農(nóng)冠已在北美、歐洲、澳大利亞、南美、印度、東南亞等多個國家/地區(qū)開展了專利化合物實驗。未來，清原農(nóng)冠將繼續(xù)把專利產(chǎn)品輸送到更多國家，為世界糧食安全貢獻中國力量。

隨著清原農(nóng)冠海外市場的開拓，我們急需有相關(guān)海外工作經(jīng)驗的專業(yè)性人才加入，同時，我們也希望與有相關(guān)需求的海外客戶建立長期的戰(zhàn)略合作關(guān)系，如有意向可聯(lián)系清原徐經(jīng)理。郵箱：xufeixiang@kingagroot.com。

Cypyrafluone was approved and registered by Pakistan, KingAgroot officially entered the overseas market

Recently, KingAgroot’s Cypyrafluone and other patented compounds were approved and registered by the Ministry of Agriculture of Pakistan, which is the first registration of this series of products overseas, marking the official start of KingAgroot foreign sales in the overseas market.

Cypyrafluone is a patent p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibiting herbicide, which was independently developed by KingAgroot. It was officially registered with the Ministry of Agriculture and Rural Affairs of the People's Republic of China on 30 August 2018. This is the first time that HPPD inhibitor be used to control grass weeds in wheat, and there is no cross-resistance with other wheat herbicides.

Pakistan has important strategic significance in the Asian market, thus KingAgroot chose Pakistan as the first overseas market. As we know, Pakistan is a typical agricultural country, mainly relies on crop farming, with wheat, rice and corn as major food crops. The wheat planting area accounts for about 40% of the country's total arable land. However, farmers are plagued by weeds such as Phalaris minor, which is highly resistant to local existing herbicides. Because of its vigorous growth and strong reproductive ability and fast expansion, this weed is seriously affecting the agricultural production in Pakistan.

In order to improve the efficiency and quality of world agricultural production and ensure world food security, KingAgroot has been carrying out scientific weed control trials in Pakistan. Data shows that Cypyrafluone can effectively control most weeds in wheat fields, especially local Phalaris minor, and help farmers greatly save planting costs.

In addition to Cypyrafluone, Bipyrazone was also registered in Pakistan. In the future, Tripyrasulfone and Fenpyrazone will also be registered and commercialized in Pakistan. Bipyrazone, Tripyrasulfone and Fenpyrazone are all new HPPD inhibitors developed by KingAgroot. Bipyrazone can be safely used to effectively control the resistant and multi-resistant broadleaf weeds such as flixweed, shepherd's-purse and chickweed. Tripyrasulfone is a top solution to multi-resistant barnyard grass and sprangletop. It is the first time that HPPD inhibitor is safely used in rice for post-emergence foliar spray treatment; Fenpyrazone is an excellent management tool for ALS-resistant weeds in maize such as crabgrass, barnyardgrass and foxtail resistant to Nicosulfuron because they have no cross-resistance.

Besides Pakistan, KingAgroot has been carrying out pesticide registrations in Indonesia, Cambodia and other Southeast Asia countries. KingAgroot has conducted 22 registration projects in overseas countries, 13 of them have obtained registration and 9 projects are under way.

As of the end of November 2021, KingAgroot has patented 189 Chinese inventions and 84 of them have been authorized; 113 PCT international inventions and accumulatively 763 have entered different countries in the world through PCT or The Paris Convention, while accumulatively 157 of them have been authorized. At present, KingAgroot’s patent compounds have been tested in North America, Europe, Australia, South America, India, Southeast Asia and other countries/regions. In the future, KingAgroot will continue to export its patented products to more countries and contribute to world food security.

With the development of the overseas market of KingAgroot, we are in urgent need of professional talents with relevant overseas working experience to join us. At the same time, we also hope to establish long-term strategic cooperative relationship with overseas customers. If you are interested, please contact Mr. Xu at: xufeixiang@kingagroot.com.